Connection
Search Results to Robert Reis
This is a "connection" page, showing the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of
Reis, Robert
Property | Value |
overview
|
My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions.
Water under the bridge (previous research):
From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.
|
One or more keywords matched the following items that are connected to
Reis, Robert
Item Type | Name |
Academic Article
|
Testing for treatment effects on gene ontology.
|
Concept
|
Anisomycin
|
Concept
|
Aminopterin
|
Concept
|
Acetylcholinesterase
|
Concept
|
Alkaloids
|
Concept
|
beta-Galactosidase
|
Concept
|
Antineoplastic Agents
|
Concept
|
Benzazepines
|
Concept
|
Biopolymers
|
Concept
|
Culture Media
|
Concept
|
Dexamethasone
|
Concept
|
Actins
|
Concept
|
Benzimidazoles
|
Concept
|
Butyrylcholinesterase
|
Concept
|
Cyclic N-Oxides
|
Concept
|
Antigens, Polyomavirus Transforming
|
Concept
|
Antigens, Viral, Tumor
|
Concept
|
Aldehydes
|
Concept
|
Hydroxyurea
|
Concept
|
Fatty Acids
|
Concept
|
Camptothecin
|
Concept
|
Azacitidine
|
Concept
|
beta-N-Acetylhexosaminidases
|
Concept
|
Aspirin
|
Concept
|
Benzylamines
|
Concept
|
Hydrogen Peroxide
|
Concept
|
DNA, Viral
|
Concept
|
Carrier Proteins
|
Concept
|
Chelating Agents
|
Concept
|
Binding Sites
|
Concept
|
Glycoside Hydrolases
|
Concept
|
Halothane
|
Concept
|
Cholinesterase Inhibitors
|
Concept
|
Detergents
|
Concept
|
Base Sequence
|
Concept
|
Carcinogens
|
Concept
|
Catalase
|
Concept
|
Deoxyribonuclease I
|
Concept
|
Dipyrone
|
Concept
|
Pharmaceutical Preparations
|
Concept
|
Enzyme Inhibitors
|
Concept
|
Transcription Factors
|
Concept
|
DNA-Binding Proteins
|
Concept
|
Fluorescent Dyes
|
Concept
|
DNA, Recombinant
|
Concept
|
DNA Transposable Elements
|
Concept
|
DNA, Mitochondrial
|
Concept
|
Globins
|
Concept
|
Intermediate Filament Proteins
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Indolizines
|
Concept
|
Membrane Proteins
|
Concept
|
Plasmids
|
Concept
|
Mannosidases
|
Concept
|
Mutagens
|
Concept
|
Glycoproteins
|
Concept
|
Chorionic Gonadotropin
|
Concept
|
Growth Inhibitors
|
Concept
|
Amyloid beta-Peptides
|
Concept
|
Porphyrins
|
Concept
|
RNA, Transfer
|
Concept
|
Thymidine
|
Concept
|
Methotrexate
|
Concept
|
RNA, Viral
|
Concept
|
Vascular Cell Adhesion Molecule-1
|
Concept
|
Nucleotides
|
Concept
|
Isoenzymes
|
Concept
|
Lipoproteins, LDL
|
Concept
|
Aphidicolin
|
Concept
|
Oxidants
|
Concept
|
Glycoprotein Hormones, alpha Subunit
|
Concept
|
Proteins
|
Concept
|
Receptor, Insulin
|
Concept
|
Superoxide Dismutase
|
Concept
|
RNA, Small Interfering
|
Concept
|
Codon, Nonsense
|
Concept
|
Proto-Oncogene Proteins
|
Concept
|
14-3-3 Proteins
|
Concept
|
RNA
|
Concept
|
Somatomedins
|
Concept
|
Peptide Fragments
|
Concept
|
Trans-Activators
|
Concept
|
Molecular Probes
|
Concept
|
Ubiquitin
|
Concept
|
Cytosine
|
Concept
|
DNA, Helminth
|
Concept
|
DNA Helicases
|
Concept
|
Proto-Oncogene Proteins p21(ras)
|
Concept
|
Neuroprotective Agents
|
Concept
|
Glutathione Transferase
|
Concept
|
Mutant Proteins
|
Concept
|
DNA
|
Concept
|
Lipopolysaccharides
|
Concept
|
Melphalan
|
Concept
|
Oxazoles
|
Concept
|
Oligonucleotide Probes
|
Concept
|
Gene Library
|
Concept
|
NF-kappa B
|
Concept
|
Hypoxanthine
|
Concept
|
RNA, Messenger
|
Concept
|
Histones
|
Concept
|
Telomerase
|
Concept
|
Phosphatidylinositol 4,5-Diphosphate
|
Concept
|
Anesthetics, Inhalation
|
Concept
|
Apolipoprotein E4
|
Concept
|
Proprotein Convertases
|
Concept
|
Rad51 Recombinase
|
Concept
|
DNA Primers
|
Concept
|
Melanins
|
Concept
|
tau Proteins
|
Concept
|
Cyclin-Dependent Kinases
|
Concept
|
Caenorhabditis elegans Proteins
|
Concept
|
Glucuronidase
|
Concept
|
Gold
|
Concept
|
Insulin
|
Concept
|
5-Methylcytosine
|
Concept
|
DNA Nucleotidyltransferases
|
Concept
|
DNA, Circular
|
Concept
|
Viral Proteins
|
Concept
|
Glucocorticoids
|
Concept
|
Scavenger Receptors, Class E
|
Concept
|
Hypoxanthine Phosphoribosyltransferase
|
Concept
|
Ligands
|
Concept
|
Indoles
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Guanosine Triphosphate
|
Concept
|
Poly U
|
Concept
|
Proteasome Inhibitors
|
Concept
|
Lipids
|
Concept
|
Heat-Shock Proteins
|
Concept
|
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
|
Concept
|
Pyridinium Compounds
|
Concept
|
DNA Probes
|
Concept
|
RNA-Directed DNA Polymerase
|
Concept
|
Poly A
|
Concept
|
RNA-Binding Proteins
|
Concept
|
Phosphatidylinositol 3-Kinases
|
Concept
|
Viral Structural Proteins
|
Concept
|
Tubulin
|
Concept
|
Deoxyribonucleases, Type II Site-Specific
|
Concept
|
Thiadiazoles
|
Concept
|
Repetitive Sequences, Nucleic Acid
|
Concept
|
Intracellular Signaling Peptides and Proteins
|
Concept
|
Oxyquinoline
|
Concept
|
G-Quadruplexes
|
Concept
|
Reactive Oxygen Species
|
Concept
|
Taq Polymerase
|
Concept
|
Phosphatidylinositol Phosphates
|
Concept
|
Apoptosis
|
Concept
|
DNA, Complementary
|
Concept
|
Peptide Nucleic Acids
|
Concept
|
Replication Origin
|
Concept
|
Proteome
|
Concept
|
alpha-Mannosidase
|
Concept
|
Apolipoprotein E3
|
Concept
|
DNA Restriction Enzymes
|
Concept
|
Chorionic Gonadotropin, beta Subunit, Human
|
Concept
|
Integrases
|
Concept
|
Recombinases
|
Concept
|
Alu Elements
|
Concept
|
Proteasome Endopeptidase Complex
|
Concept
|
Forkhead Transcription Factors
|
Concept
|
Profilins
|
Concept
|
Peptides
|
Concept
|
Serine Endopeptidases
|
Concept
|
Nucleotide Motifs
|
Concept
|
Recombinant Fusion Proteins
|
Concept
|
Cytokines
|
Grant
|
Early Events in Alzheimer Pathogenesis
|
|
- Pharmaceutical Preparations
|